Prof. Zhen YUAN

  • Room 1047, E12, University of Macau

  • (853) 8822-4989

  • (853) 8822 2456

  • zhenyuan@um.edu.mo

  • Consultation hours: Tuesdays & Fridays, 17:00 – 18:00

  • Google Scholar profile

  • 2005    Postdoc Fellow in Biomedical Engineering,  University of Florida
  • 2004    Postdoc Fellow in Physics, Clemson University
  • 2002    Postdoc Fellow in Bioengineering, National University of Singapore
  • 2001    PhD in Engineering, University of Science and Technology of China

  • 2023: Associate Director, Institute of Collaborative Innovation, University of Macau
  • 2021: Professor at Centre for Cognitive and Brain Sciences, University of Macau
  • 2021: Professor at Faculty of Health Sciences, University of Macau
  • 2019: Head, Centre for Cognitive and Brain Sciences, University of Macau
  • 2017-21: Associate Professor at Faculty of Health Sciences, University of Macau
  • 2013-17: Assistant Professor at Faculty of Health Sciences, University of Macau
  • 2012-13: Assistant Professor at School of Communication, Arizona State University
  • 2007-11: Research Assistant Professor at Dept. of Biomedical Engineering with the University of Florida

  • 2016 Award for 10 Outstanding Research in Optics (2016年中國光學重大成果獎)
  • 2017 FHS Best Teacher Award in Research
  • 华夏医学科技奖（2等奖）

  • Neuroimaging and Brain Connectome
  • Functional Near Infrared Spectroscopy (fNIRS)
  • Brain Disorders
  • Cognitive Neuroscience
  • Ultrasound stimulation, Photomodulation, TMS and tDCS

  • 2022-2024-The Key Technologies for wearable fNIRS neuroimaging-guided photomodulation of depression, FDCT 0048/2021/AGJ澳門科學技術發展基金-广东省重大项目 联合项目
  • 2020-2023-Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent， FDCT 0020/2019/AMJ:澳門科學技術發展基金-科技部重大项目 联合项目
  • 2022-2024-Development and application of a three-dimensional visualization surgical navigation system for the spine based on mixed reality. EF011/FHS-YZ/2022/ZHSTI, 1M RMB, The Key Project of Zhuhai City （珠海市重大科研專案）.
  • 2023-2025- Biomimetic Liposomes Delivered by Meningeal Lymphatic Vessels for Synergistic Therapy of Parkinson’s Disease. MOP 320,000 →MYRG2022-00054-FHS → 澳門大學多年度研究資助.
  • 2021-2024-多模态脑功能影像引导的经颅磁刺激早期干预小儿唐氏综合征， RMB-100,000→2020 Natural Science Foundation of Guangdong Province
  • 2021-2023- Dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy in the second near-infrared window, MOP 560,000 →MYRG2020-00067-FHS → 澳門大學多年度研究資助
  • 2020-2023- Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent, MOP 1,200,000→ FDCT 0020/2019/AMJ→ 澳門科學技術發展基金研究資助
  • 2018-2021- Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma, MOP 1,800,000→ FDCT 0011/2018/A1 → 澳門科學技術發展基金研究資助
  • 2019-2021- NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided photothermal/photodynamic synergistic cancer therapy, MOP 750,000→ MYRG2019-00082-FHS → 澳門大學多年度研究資助
  • 2018-2021- Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma,  MOP 900,000→ MYRG2018-00081-FHS → 澳門大學多年度研究資助
  • 2015-2018- Monitoring Responses to Neoadjuvant Chemotherapy in Breast
  • Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光声 譜成像監測乳腺癌對新輔助化療的反應, MOP 2,000,000→MYRG2015-00036-FHS→ 澳門大學多年度研究資助
  • 2016-2019- Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨- 植入物系統的活體結構和功能成像, MOP 1,310,000→ MYRG2016-00110-FHS → 澳門大學多年度研究資助
  • 2014-2017 – Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine – 光聲成像癌症納米探針的結合率, MOP 500,000 →MYRG2014-00093-FHS → 澳門大學多年度研究資助
  • 2015-2018 – Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 1,780,000 → FDCT  026/2014/A1→ 澳門科學技術發展基金研究資助
  • 2016-2019 – Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT 025/2015/A1 → 澳門科學技術發展基金研究資助
  • 2015-2018 – Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 600,000 → UM MRG →澳門大學多年度研究資助
  • 2013-2014 – Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助
  • 2016-2019 – Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 700,000 → UM MRG →澳門大學多年度研究資助
  • 2014-2017 – Social Network in Narrative Mapping using fused fMRI-EEG – 使用融合的腦電和功能核磁共振成像 社交網絡有關的神經活動 * USD 6,000,000 → Defense Advanced Research Projects Agency (DARPA) Grant, USA → 美國國防高等研究計劃署
  • 2010-2014 – Photoacoustic imaging of Epilepsy – 光聲成像癲癇活動 * USD 2,500,000 → Department of Defense (DOD) Grant, USA → 美國國防部
  • 2009-2013 – Diffuse Optical Imaging of Epilepsy –基於癲癇的擴散光學成像- USD 1,700,000 → NIH Grant, USA →美國國家衛生研究院
  • 2004-2009 – Diffuse Optical Imaging of Osteoarthritis – 擴散光學成像關節炎 * USD 1,700,000 → NIH Grant, USA →美國國家衛生研究院
  • 2004-2008 – Diffuse optical imaging of breast cancer – 擴散光學成像乳腺癌 * USD 1,400,000 → NIH Grant, USA →美國國家衛生研究院

  • 中国生物医学光子学学会常务委员
  • 中国医药生物技术协会医学成像技术分会委员会委员
  • 中国光学学会生物医学光子学学会常委
  • Senior Member of SPIE (since 2008)
  • Senior Member of OSA (since 2010)
  • Committee Member of China Optical Society
  • Core Committee Member of China Biomedical Optics Society
  • Committee Members of China Biomedical Engineering Society
  • 中国解剖学会委员
  • 中国神经学会理事
  • 中国成瘾与脑科学分会委员
  • Vice Chair, Macau Society of Nuclear Medicine and Molecular Imaging
  • 2020-, 副主席（Vice Chair）  澳門超分子化學與生物材料學會

Editorial Board/Associate Editor

  • Senior Associate Editor of BMC Medical Imaging
  • Editor of Journal of Innovative Optical Health Sciences
  • Associate Editor of Frontiers in Human Neuroscience
  • Editorial Member of Quantitative Imaging in Medicine and Surgery
  • Editorial Member of Bio Integration
  • Special issue Editor for Biomedical Research International
  • Special issue Editor for Journal of Innovative Optical Health Sciences
  • Special issue Editor for Frontiers in Human Neuroscience
  • Special issue Editor for Frontiers in Psychology
  • Special issue Editor for Biomed Research International

Grant Review (selected)

  • BRAIN Initiative R21, NIH/NEI, US
  • L’Agence Nationale de la Recherche, France
  • External grant reviewer for Science Foundation of Czech Republic, Czech
  • Brain Peer Review Committee, the American Heart Association, US
  • External grant reviewer for Israel Science Foundation, Israel
  • NIH: BMIT: “Biomedical Imaging Technology”, US
  • NIH: SBMI : “Small Business Medical Imaging” , US
  • External grant reviewer for Australia National Science Foundation, Australia
  • External grant reviewer for China National Science Foundation, China
  • External grant reviewer for Guangdong Province Science Foundation, China
  • External grant reviewer for Key Projects of MOST, PRC, China
  • NIH: NIDA Cutting-Edge Basic Research Awards R21 panel, US
  • External reviewer of University Fund for Nanyang Technological University, Singapore

Journal Reviewer (selected)

  • ACS Nano, Nano Letters, Theranostics, Advanced Functional Materials, Advanced Materials, ACS Applied Materials and Interfaces, JACS, Biomaterials, Advanced Science
  • Optics Letters, Optics Express, Journal of Biophotonics, IEEE Transaction on Biomedical Engineering, Applied Physics Letters, Medical Physics
  • Neuroimage, Human brain Mapping, Brain, Journal of Neuroscience, Behavioral Research and Therapy, Brain Structure and Functions, Neural Networks, eNeuron
  • National Science Review, PNAS, eLife, Nature Photonics, Nature Biomedical Engineering, Nature Communication, Science Advances, Neuron

  • Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, US patent No. PCT/US2008/055894.
  • METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS US PATENT: WO/2009/011934
  • 一種融合光聲顯微，螢光顯微和超聲成像於一體的多模態顯微成像系統。中國專利號: 201820951744.5.

Publication records (Google Scholar Profile)

  1. Xianyuan Wei, Bin Xuea, Shuangchen Ruanb, Jintong Guo, Yujing Huang, Xiaorui Geng, Dan, Wang, Cangtao Zhou, Jun Zheng, Zhen Yuan.* Supercharged precision killers: genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni, Sciences Advances (Accepted).
  2. Yan Han, Xinglin Zeng, Lin Hua, Xingping Quan, Ying Chen, Manfei Zhou, Yaochen Chuang, Yang Li, Shengpeng Wang, Xu Shen, Lai Wei, Zhen Yuan*, Yonghua Zhao*. The fusion of multi-omics profile and multimodal EEG data contributes to the personalized diagnostic strategy for neurocognitive disorders. Microbiome, 12(1), 12-21 (2024).
  3. J Liu, D Gao, D Hu, S Lan, Y Liu, H Zheng, Z Yuan*, Z Sheng*. Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson’s Disease. Research 6, 0030 (2023).
  4. Juan Zhang, Yihui Wang, Yidi Mao, Chantat Leong, Zhen Yuan*. Shared Minds, Shared Feedback: tracing the influence of parental feedback on shared neural patterns. Cerebral Cortex, 34(1), bhad489 (2024).
  5. J Zhang, Y Wang, C Leong, Y Mao, Z Yuan*. Bridging Stories and Science: An fNIRS-based hyperscanning investigation into child learning in STEM. NeuroImage 285, 120486 (2024)
  6. X Xia, X Zeng, F Gao, L Hua, S Huang, Z Yuan*. Striatonigrostriatal connectivity‐based cross‐species parcellation of human and macaque substantia nigra. Human Brain Mapping, 44 (12), 4590-4604 (2023).
  7. Fei Gao, Lin Hua, Paulo Armada-da-Silva, Juan Zhang, Defeng Li, Zhiyi Chen, Chengwen Wang, Meng Du, Zhen Yuan*. Shared and distinct neural correlates of first and second language morphological processing in bilingual brain. NPJ Science of Learning, 8(1),33-40(2023).
  8. X Zeng, X Han, F Gao, Y Sun, Z Yuan*. Abnormal structural alterations and disrupted functional connectivity in behavioral addiction: A meta-analysis of VBM and fMRI studies. Journal of Behavioral Addictions. https://doi.org/10.1556/2006.2023.00025 (2023).
  9. L Hua, F Gao, X Xia, Q Guo, Y Zhao, S Huang, Z Yuan*. Individual-specific functional connectivity improves prediction of Alzheimer’s disease’s symptoms in elderly people regardless of APOE ε4 genotype. Communications Biology 6 (1), 581 (2023).
  10. Zhao Zhang, Zixiang Wei, Jintong Guo, Jinxiao Lyu, Bingzhe Wang, Gang Wang, Chunfei Wang, Liqiang Zhou, Zhen Yuan, Guichuan Xing, Changfeng Wu, Xuanjun Zhang. Nature Communications, 15(1), 170-176, 2024.
  11. Xinglin Zeng, Wen Tang, Fei Gao, Ziyue Tang, Zhou Zhang, Juan Zhang, Meng Du, Zhiyi Chen, Xueli Chen, Zhen Yuan*. Behavioral modeling and neuroimaging of impaired risky decision making in patients with chronic musculoskeletal pain. Neurophotonics, 10(2), 020901-020901 (2023).
  12. Zhao Zhang, Zixiang Wei, Jintong Guo, Jinxiao Lyu, Bingzhe Wang, Gang Wang, Chunfei Wang, Liqiang Zhou, Zhen Yuan, Guichuan Xing, Changfeng Wu, Xuanjun Zhang. Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy. Nature Communications.15(1),170-181(2023).
  13. Hua L, Gao F, Leong C, Yuan Z*. Neural decoding dissociates perceptual grouping between proximity and similarity in visual perception. Cereb Cortex. 2022 Aug 17:bhac308. doi: 10.1093/cercor/bhac308. Epub ahead of print. PMID: 35973163. (2022).
  14. F Gao, R Wang, P Armada-da-Silva, M Wang, H Lv, C Leong, Z Yuan*. How the brain encodes morphological constraints during Chinese word reading: An EEG-fNIRS study. Cortex, 154: 184-196 (2022).
  15. Xia, X. L., Gao, F. & Yuan, Z*. Species and Individual Differences and Connectional Asymmetry of Broca’s Area in Humans and Macaques. Neuroimage, 118583 (2021).
  16. Xinglin Zeng, Xinyang Han, Dong Zheng, Ping Jiang, Zhen Yuan*. Similarity and difference in large-scale functional network alternations between behavioral addictions and substance use disorder: a comparative meta-analysis. Psychological Medicine, 1-15(2024).
  17. XL Xia, Zhen Yuan*. Striatonigrostriatal connectivity-based cross-species parcellation of human and macaque substantia nigra. Cerebral Cortex, bhad057 (2023).
  18. Hua L, Gao F, Leong C, Yuan Z*. Neural decoding dissociates perceptual grouping between proximity and similarity in visual perception. Cerebral Cortex. 2022 Aug 17:bhac308. doi: 10.1093/cercor/bhac308. Epub ahead of print. PMID: 35973163.
  19. F Gao, J Wang, CG Zhao, Z Yuan*. Word or morpheme? Investigating the representation units of L1 and L2 Chinese compound words in mental lexicon using a repetition priming paradigm. International Journal of Bilingual Education and Bilingualism, 25 (7), 2382-2396 (2022).
  20. F Gao, R Wang, P Armada-da-Silva, M Wang, H Lv, C Leong, Z Yuan*. How the brain encodes morphological constraints during Chinese word reading: An EEG-fNIRS study. Cortex, 154: 184-196 (2022).
  21. X Zhang, Y Qiu, J Li, C Jia, J Liao, K Chen, L Qiu, Z Yuan* , R Huang*. Neural correlates of transitive inference: An SDM meta-analysis on 32 fMRI studies. NeuroImage, 119354 (2022).
  22. Yan Han, Xingping Quan, Yaochen Chuang, Qiaoxing Liang, Yang Li, Zhen Yuan, Ying Bian, Lai Wei, Ji Wang, Yonghua Zhao. A multi‐omics analysis for the prediction of neurocognitive disorders risk among the elderly in Macao. Clinical and translational medicine, 12(60,e909) (2022).
  23. Xia, X. L., Gao, F. & Yuan, Z*. Species and Individual Differences and Connectional Asymmetry of Broca’s Area in Humans and Macaques. Neuroimage,118583 (2021).
  24. F Gao, J Wang, C Wu, M Wang, J Zhang, Z Yuan*. The neural dynamics associated with lexicality effect in reading single Chinese words, pseudo-words and non-words. Cognitive Neurodynamics, 1-11 (2021).
  25. Z Hu, KF Lam, Z Yuan. Effective Connectivity of the Fronto-Parietal Network during the Tangram Task in a Natural Environment. Neuroscience 422, 202-211 (2019).
  26. Z Hu, KF Lam, YT Xiang, Z Yuan*. Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather than Reasoning. International Journal of Biological Sciences, 15 (6), 1148-1157(2019).
  27. MY Wang, FM Lu, Z Hu, J Zhang, Yuan, Zhen*. Optical mapping of prefrontal brain connectivity and activation during emotion anticipation. Behavioural Brain Research, (350): 122-128 (2018).
  28. X Lin, L Sai, Yuan, Zhen*. Detecting concealed information with fused electroencephalography and functional near-infrared spectroscopy. Neuroscience, 386, 284-294 (2018).
  29. HF Ieong, Yuan, Zhen*. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study. Neurophotonics, 5 (2): 025011 (2018).
  30. Zhang ZM, Wang MY, Guo X, Miao X, Zhang T, Gao D, Yuan Z *. Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behav Res Ther, 97, 96-104 (2017).
  31. C Wu, J Zhang, Z Yuan*. Exploring affective priming effect of emotion-label words and emotion-laden words: an event-related potential study. Brain Sciences 11 (5), 553 (2021). Brain imaging and behavior, 15, pages1201–1210 (2021).
  32. MY Wang, Z Yuan*. EEG Decoding of Dynamic Facial Expressions of Emotion: Evidence from SSVEP and Causal Cortical Network Dynamics, Neuroscience 459, 50-58 (2021).
  33. Zhishan Hu; Juan Zhang; Lingyan Zhang; Yu-Tao Xiang; Zhen Yuan*. Linking brain activation to topological organization in the frontal lobe as a synergistic indicator to characterize the difference between various cognitive processes of executive functions. Neurophotonics, 6(2), 025008 (2019).
  34. H Ren, MY Wang, Y He, Z Du, J Zhang, J Zhang, D Li, Z Yuan*. A novel phase analysis method for examining fNIRS neuroimaging data associated with Chinese/English sight translation. Behavioural Brain Research 361, 151-158(2019).
  35. Juan Zhang, Yaxuan Meng, Chenggang Wu, Yu-Tao Xiang, Zhen Yuan*. Non-speech and Speech Pitch Perception among Cantonese-speaking Children with Autism Spectrum Disorder: an ERP Study. Neuroscience letters, 703, 205-212 (2019).
  36. Z Hu, J Zhang, TA Couto, S Xu, P Luan, Yuan, Zhen*. Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex during Chinese Character Recognition. Brain Topography, Brain Topography 31, 1014–1028 (2018).
  37. X Lin, L Sai, Yuan, Zhen*. Detecting concealed information with fused electroencephalography and functional near-infrared spectroscopy. Neuroscience 386, 284-294 (2018).
  38. HF Ieong, Yuan, Zhen*. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study. Neurophotonics 5 (2): 025011 (2018).
  39. MY Wang, FM Lu, Z Hu, J Zhang, Yuan, Zhen*. Optical mapping of prefrontal brain connectivity and activation during emotion anticipation. Behavioural Brain Research (350): 122-128 (2018).
  40. X Lin, VLC Lei, D Li, Yuan, Zhen*. Which is more costly in Chinese to English simultaneous interpreting,“pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study. Neurophotonics 5 (2), 025010 (2018).
  41. Y He, MY Wang, D Li, Yuan, Zhen*. Optical mapping of brain activation during the English to Chinese and Chinese to English sight translation. Biomedical Optics Express 8 (12), 5399-5411 (2017).
  42. Zhong-Ming Zhang, Meng-Yun Wang, Xiaowei Guo, Xiaocui Miao, Ting Zhang, Dong Gao, Yuan, Zhen*. Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behaviour Research and Therapy, 97:6-104 (2017).
  43. FM Lu, JS Zhou, XP Wang, YT Xiang, Yuan, Zhen*. Short-and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neuroscience, 351:96-107(2017).
  44. Liu, CH, Ma, X, Yuan, Z*, et al.. Decreased resting-state activity in the precuneus is associated with depressive episodes in recurrent depression. The Journal of Clinical Psychiatry, 13(3). 1-8 (2017).
  45. Lu, FM, & Yuan, Z*. PET/SPECT Molecular Imaging in Clinical Neuroscience: Recent Advances in the Investigation of CNS Diseases. Quantitative Imaging in Medicine and Surgery, 5(3): 433-447 (2015).
  46. MY Wang, P Luan, J Zhang, YT Xiang, H Niu, Yuan, Zhen*. Concurrent mapping of brain activation from multiple subjects during social interaction by hyperscanning: a mini-review. Quant Imaging Med Surg, 8(8): 819–837 (2018).
  47. Yuan, Z*. Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis. Journal of Biomedical Optics, 18(10): 106011(1)-106011(10) (2013).
  48. Yuan, Z*. Combining independent component analysis and Granger causality to investigate brain network dynamics with fNIRS measurements. Biomedical Optics Express, 4(11): 2629-2643 (2013).
  49. C Wu, J Zhang, Z Yuan. An ERP investigation on the second language and emotion perception: The role of emotion word type. International Journal of Bilingual Education and Bilingualism 25 (2), 539-551 (2022).
  50. C Wu, J Zhang, Z Yuan*. Exploring affective priming effect of emotion-label words and emotion-laden words: an event-related potential study. Brain Sciences 11 (5), 553 (2021). Brain imaging and behavior, 15, pages1201–1210 (2021).